Monday, November 12, 2018

BacterioFiles 361 - Figuring Fungus's Forcing Fly Functions

Fruit fly infected with fungus
By Elya et al 2018;7:e34414
This episode: Bringing a fungus that makes zombie flies into the lab makes a good model for studying microbial mind-control!

Thanks to Dr. Carolyn Elya for her contribution!
Download Episode (12.1 MB, 13.25 minutes)

Show notes:
Microbe of the episode: Dipteran brevidensovirus 2

News item

Videos of fly fungus infection progression

Journal Papers:
Elya C, Lok TC, Spencer QE, McCausland H, Martinez CC, Eisen M. 2018. Robust manipulation of the behavior of Drosophila melanogaster by a fungal pathogen in the laboratory. eLife 7:e34414.

Other interesting stories:

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Episode outline:

Monday, November 5, 2018

BacterioFiles 360 - Fellow Phages Fight Fortifications

Bacteriophage
By Rolf Lood, Matthias Mörgelin,
Anna Holmberg, Magnus Rasmussen
and Mattias Collin
BMC Microbiology 2008,
8:139 doi:10.1186/1471-2180-8-139
CC BY 2.5
This episode: Bacteriophages with defenses against bacterial CRISPR defenses have to work together to succeed!

Thanks to Drs. Edze Westra and Stineke van Houte for their contributions, and to Calvin Cornell for suggesting this story!
Download Episode (9.6 MB, 10.5 minutes)

Show notes:
Microbe of the episode: Lactobacillus casei subsp. alactosus

News item 1/News item 2

Journal Papers:
Borges AL, Zhang JY, Rollins MF, Osuna BA, Wiedenheft B, Bondy-Denomy J. 2018. Bacteriophage Cooperation Suppresses CRISPR-Cas3 and Cas9 Immunity. Cell 174:917-925.e10.

Landsberger M, Gandon S, Meaden S, Rollie C, Chevallereau A, Chabas H, Buckling A, Westra ER, Houte S van. 2018. Anti-CRISPR Phages Cooperate to Overcome CRISPR-Cas Immunity. Cell 174:908-916.e12.

Other interesting stories:

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Episode outline:

Monday, October 29, 2018

BacterioFiles 359 - Prokaryotes Provoke Perpendicular Punishment

Strain resistant to toxin
quickly takes over colony
By Despoina Mavridou
This episode: Some bacteria produce DNA-targeting toxins, which provokes a similar retaliation from other strains. Sometimes this hurts the provoker, but sometimes it is very helpful to them!

Thanks to Dr. Despoina Mavridou for her contribution!
Download Episode (7.9 MB, 8.4 minutes)

Show notes:
Microbe of the episode: Mycobacterium virus Athena

News item

Journal Paper:
Gonzalez D, Sabnis A, Foster KR, Mavridou DAI. 2018. Costs and benefits of provocation in bacterial warfare. Proc Natl Acad Sci 115:7593–7598.

Other interesting stories:

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Episode outline:

Sunday, October 21, 2018

State Fair

Last interruption for a while: I was participating in the NC State Fair all weekend. It was fun and there were even microbe exhibits there! Though mostly ones encouraging hand-washing.

Monday, October 15, 2018

BacterioFiles 358 - elegans Endures Edifying Enterococcus

Caenorhabditis elegans
By Bob Goldstein, UNC Chapel Hill
Own work, CC BY-SA 3.0
This episode: Roundworms and not-too-irritating bacteria quickly evolve a beneficial relationship when under threat from other bacterial pathogens!
Download Episode (7.5 MB, 8.1 minutes)

Show notes:
Microbe of the episode: Siegesbeckia yellow vein betasatellite

News item

Journal Paper:
Rafaluk‐Mohr C, Ashby B, Dahan DA, King KC. 2018. Mutual fitness benefits arise during coevolution in a nematode-defensive microbe model. Evol Lett 2:246–256.

Other interesting stories:

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Episode outline:

Sunday, October 7, 2018

No episode this week

Family event this weekend, so I didn't have time to get an episode up. See you next week!

Monday, October 1, 2018

BacterioFiles 357 - Colossal Contagion Codes Catabolism

Tetraselmis alga
By: David Patterson and
Bob Andersen, CC BY-NC 3.0
This episode: A new giant virus infecting marine algae brings its own genes related to fermentation, generating energy in the absence of oxygen!

Thanks to Drs. Chris Schvarcz and Grieg Steward for their contributions!

Download Episode (14 MB, 15.25 minutes)

Show notes:
Microbe of the episode: Borrelia anserina

News item

Journal Paper:
Schvarcz CR, Steward GF. 2018. A giant virus infecting green algae encodes key fermentation genes. Virology 518:423–433.

Other interesting stories:

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Monday, September 24, 2018

BacterioFiles 356 - Beams Boost Bolstered Bacteria

Nanomaterial-enhanced
tumor-targeting bacterium
From: Zheng et al. 2018,
Nat Commun 9:1680
This episode: Combining cells with light-absorbing nanomaterials can help tumor-targeting bacteria produce more anticancer compound!

Download Episode (10.4 MB, 11.4 minutes)

Show notes:
Microbe of the episode: Maruca vitrata nucleopolyhedrovirus

Here's a paper I found that actually shows carbon dot nanomaterials enhancing bacterial nitrogen fixation

Journal Paper:
Zheng D-W, Chen Y, Li Z-H, Xu L, Li C-X, Li B, Fan J-X, Cheng S-X, Zhang X-Z. 2018. Optically-controlled bacterial metabolite for cancer therapy. Nat Commun 9:1680.

Other interesting stories:

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Episode outline:

Sunday, September 16, 2018

Hurricane Florence

No episode this week, thanks to Hurricane Florence. I'm ok though and will be back next week! Everyone stay safe.

Monday, September 10, 2018

BacterioFiles 355 - Photon Factors Favor Fancy Fuels

Saccharomyces cerevisiae yeast
This episode: Engineering yeast to control their metabolism using light and dark for the production of advanced biofuels and chemicals!

Download Episode (16.1 MB, 17.7 minutes)

Show notes:
Microbe of the episode: Equine arteritis virus

News item

Journal Paper:
Zhao EM, Zhang Y, Mehl J, Park H, Lalwani MA, Toettcher JE, Avalos JL. 2018. Optogenetic regulation of engineered cellular metabolism for microbial chemical production. Nature 555:683–687.

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Episode outline:

Monday, September 3, 2018

BacterioFiles 354 - Prokaryote Protection Promotes Protein Passing

Pectobacterium cells
By: The James Hutton Institute
This episode: The bacterial immune system, CRISPR-Cas, can enhance gene transfer via transduction (phages carrying bacteria DNA) despite preventing it via conjugation!

Thanks to Bridget Watson for her contribution!

Download Episode (14.9 MB, 16.3 minutes)

Show notes:
Microbe of the episode: Human polyomavirus 8

Journal Paper:
Watson BNJ, Staals RHJ, Fineran PC. 2018. CRISPR-Cas-Mediated Phage Resistance Enhances Horizontal Gene Transfer by Transduction. mBio 9:e02406-17.

Other interesting stories:

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Monday, August 27, 2018

BacterioFiles 353 - Pathogen Prevents Pathogen Pervasion

Streptococcus (green) and
Staphylococcus (red)
together in biofilm.
By: Reddinger et al, 2018, mBio
This episode: Some bacteria that can cause pneumonia can prevent other bacteria from doing the same!

Download Episode (9.6 MB, 10.5 minutes)

Show notes:
Microbe of the episode: Bell pepper mottle virus

Journal Paper:
Reddinger RM, Luke-Marshall NR, Sauberan SL, Hakansson AP, Campagnari AA. 2018. Streptococcus pneumoniae Modulates Staphylococcus aureus Biofilm Dispersion and the Transition from Colonization to Invasive Disease. mBio 9:e02089-17.

Other interesting stories:

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Episode outline:

Monday, August 20, 2018

BacterioFiles 352 - Staphylococcus Stops Skin Swellings

Staphylococcus epidermidis
This episode: A harmless strain of bacteria on the skin produces a compound that can prevent tumors from forming!

Download Episode (9.2 MB, 10 minutes)

Show notes:
Microbe of the episode: Hamiltonella virus APSE1

News item

Journal Paper:
Nakatsuji T, Chen TH, Butcher AM, Trzoss LL, Nam S-J, Shirakawa KT, Zhou W, Oh J, Otto M, Fenical W, Gallo RL. 2018. A commensal strain of Staphylococcus epidermidis protects against skin neoplasia. Sci Adv 4:eaao4502.

Other interesting stories:

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Episode outline:

Monday, August 13, 2018

BacterioFiles 351 - Tupanvirus Transports Translation Tools

Tupanvirus pictures
From: Abrahão et al,
2018, Nat Commun 9:749
This episode: A new giant virus has genes for a surprisingly complete system of protein synthesis!

Download Episode (10.1 MB, 11.1 minutes)

Show notes:
Microbe of the episode: Phocid alphaherpesvirus 1

Video of tupanvirus intracellular factory

Journal Paper:
Abrahão J, Silva L, Silva LS, Khalil JYB, Rodrigues R, Arantes T, Assis F, Boratto P, Andrade M, Kroon EG, Ribeiro B, Bergier I, Seligmann H, Ghigo E, Colson P, Levasseur A, Kroemer G, Raoult D, La Scola B. 2018. Tailed giant Tupanvirus possesses the most complete translational apparatus of the known virosphere. Nat Commun 9:749.

Other interesting stories:

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Episode outline:

Monday, August 6, 2018

BacterioFiles 350 - Microbes Mysteriously Make Methane

Nitrogenase protein structure
By Jjsjjsjjs - Own work
CC BY-SA 3.0
This episode: A version of the microbial enzyme that fixes nitrogen can also convert carbon dioxide to methane!

Download Episode (11.8 MB, 12.9 minutes)

Show notes:
Microbe of the episode: Human mastadenovirus D

Journal Paper:
Zheng Y, Harris DF, Yu Z, Fu Y, Poudel S, Ledbetter RN, Fixen KR, Yang Z-Y, Boyd ES, Lidstrom ME, Seefeldt LC, Harwood CS. 2018. A pathway for biological methane production using bacterial iron-only nitrogenase. Nat Microbiol 3:281–286.

Other interesting stories:

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Episode outline:

Monday, July 30, 2018

BacterioFiles 349 - Magnet Microbes Make Millivolts

Magnetotactic bacteria with
magnetosome chains visible
From: Edouard Alphandéry
Front. Bioeng. Biotechnol.
DOI: 10.3389/fbioe.2014.00005
This episode: Bacteria that contain tiny magnets can generate an electric current!

Download Episode (6.8 MB, 7.4 minutes)

Show notes:
Microbe of the episode: Mamastrovirus 2

Journal Paper:
Smit B.A., Van Zyl E., Joubert J.J., Meyer W., Prévéral S., Lefèvre C.T., Venter S.N. 2018. Magnetotactic bacteria used to generate electricity based on Faraday’s law of electromagnetic induction. Lett Appl Microbiol 66:362–367.

Other interesting stories:

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Episode outline:

Monday, July 23, 2018

BacterioFiles 348 - Huge Host Hackers Have Historic Histones

Marseillevirus
By: Swiss Institute of Bioinformatics
This episode: Giant viruses produce DNA-packing proteins that seem to have branched off from eukaryotes far back in evolutionary history!

Download Episode (6 MB, 6.5 minutes)

Show notes:
Microbe of the episode: Caulobacter maris

News item

Journal Paper:
Erives AJ. 2017. Phylogenetic analysis of the core histone doublet and DNA topo II genes of Marseilleviridae: evidence of proto-eukaryotic provenance. Epigenetics & Chromatin 10:55.

Other interesting stories:
  • Swimming bacteria can affect liquid viscosity, to the point of superfluidity
  • Tiny soil roundworms can sense and avoid pathogens by their gases
  • Beetle bacterium makes defensive compound with genes taken from an ocean microbe

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    Episode outline:

    Monday, July 16, 2018

    BacterioFiles 347 - Adenovirus Adapter Allows Assignment

    Virus and shielded virus
    Schmid et al, 2018, Nat Commun
    This episode: Adding adapters to anti-cancer virus helps it avoid destruction by the body so it can target the tumors!

    Thanks to Dr. Andreas Plückthun for his contribution!

    Download Episode (7.8 MB, 8.5 minutes)

    Show notes:
    Microbe of the episode: Tomato leaf curl Vietnam virus

    News item

    Journal Paper:
    Schmid M, Ernst P, Honegger A, Suomalainen M, Zimmermann M, Braun L, Stauffer S, Thom C, Dreier B, Eibauer M, Kipar A, Vogel V, Greber UF, Medalia O, Plückthun A. 2018. Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control. Nat Commun 9:450.

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    Episode outline:

    Monday, July 9, 2018

    BacterioFiles 346 - Prokaryote Prey Plug Picoalgae

    Alga (C) with bacterial prey (P)
    By: Kamennaya et al,
    PLOS Biol 2018
    This episode: Very small ocean algae consume bacterial prey of a similar size to themselves by engulfing them only partially!

    Download Episode (8.9 MB, 9.7 minutes)

    Show notes:
    Microbe of the episode: Bradyrhizobium japonicum

    Journal Paper:
    Kamennaya NA, Kennaway G, Fuchs BM, Zubkov MV. 2018. “Pomacytosis”—Semi-extracellular phagocytosis of cyanobacteria by the smallest marine algae. PLOS Biol 16:e2003502.

    Other interesting stories:

  • Using nanomagnets to control quorum sensing by pulling bacteria together (paper)

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    Episode outline:

    Monday, July 2, 2018

    BacterioFiles 345 - Super Sonic Cell Sacs

    Anabaena flos-aquae,
    a source for gas vesicle genes
    This episode: Protein bags of gas in bacteria could help make ultrasound imaging more versatile!

    Download Episode (7.6 MB, 8.25 minutes)

    Show notes:
    Microbe of the episode: Cronobacter virus Esp2949-1

    News item

    Journal Paper:
    Bourdeau RW, Lee-Gosselin A, Lakshmanan A, Farhadi A, Kumar SR, Nety SP, Shapiro MG. 2018. Acoustic reporter genes for noninvasive imaging of microorganisms in mammalian hosts. Nature 553:86–90.

    Other interesting stories:
  • Laxatives shown very disruptive to gut microbes in mice
  • Evidence not good that probiotics can reduce anxiety in people

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    Episode outline:

    Monday, June 25, 2018

    BacterioFiles 344 - Bacteriophages Bypass Body Barriers

    Cell culture setup
    Nguyen et al, 2017,
    mBio 8:e01874-17
    This episode: Phages may be passing through the barriers in our body all the time!

    Thanks to Dr. Jeremy Barr for his contribution!
    Download Episode (13.2 MB, 14.5 minutes)

    Show notes:
    Microbe of the episode: Rhodobacter virus RcCronus

    News item

    Journal Paper:
    Nguyen S, Baker K, Padman BS, Patwa R, Dunstan RA, Weston TA, Schlosser K, Bailey B, Lithgow T, Lazarou M, Luque A, Rohwer F, Blumberg RS, Barr JJ. 2017. Bacteriophage Transcytosis Provides a Mechanism To Cross Epithelial Cell Layers. mBio 8:e01874-17.

    Other interesting stories:
  • Yeast species uses same codon for two different amino acids (paper)

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    Episode outline:

    Sunday, June 17, 2018

    BacterioFiles 343 - Super Cells Save Susceptible Species

    Deinococcus radiodurans
    This episode: Very radiation-resistant bacteria can protect other, less-resistant microbes from some of the effects of chronic radiation!

    Download Episode (9.7 MB, 10.6 minutes)

    Show notes:
    Microbe of the episode: Paramecium bursaria Chlorella virus CA4A

    News item

    Journal Paper:
    Shuryak I, Matrosova VY, Gaidamakova EK, Tkavc R, Grichenko O, Klimenkova P, Volpe RP, Daly MJ. 2017. Microbial cells can cooperate to resist high-level chronic ionizing radiation. PLOS ONE 12:e0189261.

    Other interesting stories:
  • Panda gut microbes help them detoxify cyanide in their diet (paper)
  • Modified probiotics can detect and inhibit cholera in baby mice

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    Episode outline:

    Monday, June 11, 2018

    BacterioFiles 342 - Cyanide Stops Cell Suckers

    Chromobacterium growing on agar
    This episode: Some bacteria can defend themselves from bacterial predators by producing cyanide!

    Thanks to Dr. Robert Mitchell for his contribution!

    Download Episode (7.7 MB, 8.4 minutes)

    Show notes:
    Microbe of the episode: Dyoepsilonpapillomavirus 1

    News item

    Journal Paper:
    Mun W, Kwon H, Im H, Choi SY, Monnappa AK, Mitchell RJ. 2017. Cyanide Production by Chromobacterium piscinae Shields It from Bdellovibrio bacteriovorus HD100 Predation. mBio 8:e01370-17.

    Other interesting stories:
  • Using bacterial DNA to estimate movement of river water
  • Making bacteria produce biologic drugs that last longer in the body
  • Fungal pigment could be a useful semiconductor
  • Parasitic microbe uses chemical defense against defenses of fungus-growing ants

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    Episode outline:

    Monday, June 4, 2018

    BacterioFiles 341 - Cancer Killer Could Cure Cryptic Contagion

    HIV particles on infected cell
    By Liza Gross,
    PLOS Biology 2006, e445
    CC BY 2.5
    This episode: A virus designed to target cancer could also help eliminate hidden HIV infections!

    Thanks to Nischal Ranganath for his contribution!

    Download Episode (8.7 MB, 9.5 minutes)

    Show notes:
    Microbe of the episode: Streptomyces pluricolorescens

    News item

    Journal Paper:
    Ranganath N, Sandstrom TS, Schinkel B, C S, Côté SC, Angel JB. 2018. The Oncolytic Virus MG1 Targets and Eliminates Cells Latently Infected With HIV-1: Implications for an HIV Cure. J Infect Dis 217:721–730.

    Other interesting stories:
  • Gut microbes could affect immune defense against liver cancer

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

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    Episode outline:

    Sunday, May 27, 2018

    BacterioFiles 340 - Plasmid Promotes Plant Pathogenesis

    Pathogenic Rhodococcus causing
    disfigurement
    From: Savory et al, eLife 6:e30925
    This episode: Some bacteria living around plants can become pathogenic just by gaining a few genes!

    Thanks to Skylar Fuller for her contribution!

    Download Episode (9.4 MB, 10.3 minutes)

    Show notes:
    Microbe of the episode: Alternanthera yellow vein betasatellite

    News item

    Journal Paper:
    Savory EA, Fuller SL, Weisberg AJ, Thomas WJ, Gordon MI, Stevens DM, Creason AL, Belcher MS, Serdani M, Wiseman MS, Grünwald NJ, Putnam ML, Chang JH. 2017. Evolutionary transitions between beneficial and phytopathogenic Rhodococcus challenge disease management. eLife 6:e30925.

    Other interesting stories:
  • More gut microbe diversity could be good for arteries
  • Human gut microbes have enzymes that break down specific plant toxins (paper)
  • Gut microbes ferment fiber and modify immune response to protect mice from flu
  • Cooperation of plants and fungi breaks down if one finds alternative lifestyle (paper)
  • Disproven "arsenic in the DNA" bacterium actually has interesting arsenic detox strategies (paper)

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

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    Episode outline:

    Monday, May 21, 2018

    BacterioFiles 339 - Medical Microbiota Measurement

    Clostridium difficile bacteria
    This episode: Fecal microbiota transplants work just as well when taken in pill form as when delivered through a tube!

    Download Episode (10.5 MB, 11.5 minutes)

    Show notes:
    Microbe of the episode: Halobacterium halobium

    News item

    Journal Paper:
    Kao D, Roach B, Silva M, Beck P, Rioux K, Kaplan GG, Chang H-J, Coward S, Goodman KJ, Xu H, Madsen K, Mason A, Wong GK-S, Jovel J, Patterson J, Louie T. 2017. Effect of Oral Capsule- vs Colonoscopy-Delivered Fecal Microbiota Transplantation on Recurrent Clostridium difficile Infection: A Randomized Clinical Trial. J Am Med Assoc 318:1985–1993.

    Other interesting stories:
  • Protein that can form prions important for protecting mice from influenza (paper)
  • Figuring out how bacteria in fruit flies kill only males
  • Healthy skin microbes could help treat eczema
  • Good gut microbe is very comfortable with immune system
  • Archaea in bogs could be good microbes for plants too (paper)

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

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    Episode outline:

    Monday, May 14, 2018

    BacterioFiles 338 - Maverick Mouse Microbes Mitigate Maladies

    House mouse,
    Mus musculus domesticus
    This episode: Gut microbe transplants from wild mice protect lab mice from disease!

    Download Episode (9.8 MB, 10.7 minutes)

    Show notes:
    Microbe of the episode: Cabassou virus

    News item

    Journal Paper:
    Rosshart SP, Vassallo BG, Angeletti D, Hutchinson DS, Morgan AP, Takeda K, Hickman HD, McCulloch JA, Badger JH, Ajami NJ, Trinchieri G, Pardo-Manuel de Villena F, Yewdell JW, Rehermann B. 2017. Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance. Cell 171:1015-1028.e13.

    Other interesting stories:
  • Phage cocktail can eliminate pathogen with minimal collateral damage
  • Preventive probiotics given with antibiotics can help keep C. diff away
  • Early exposure to dust and bacteria linked with less immune response to stress
  • Viruses that help wasps parasitize caterpillars also inhibit plant defenses
  • Only one microbe species can live in extremely acidic, almost boiling lake

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

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    Episode outline:

    Monday, April 30, 2018

    BacterioFiles 337 - Gathering Gut Groupings Graphics

    Bacteria labeled using FISH
    By Velocity2222X
    CC BY-SA 3.0
    This episode: A simplified bacterial community in mouse guts doesn't have much community structure, relative to other body areas!

    Download Episode (8.8 MB, 9.6 minutes)

    Show notes:
    Microbe of the episode: Rhodomicrobium vannielii

    News item

    Journal Paper:
    Welch JLM, Hasegawa Y, McNulty NP, Gordon JI, Borisy GG. 2017. Spatial organization of a model 15-member human gut microbiota established in gnotobiotic mice. Proc Natl Acad Sci 114:E9105–E9114.

    Other interesting stories:
  • Studying the microbes found in Chinese hazy air (paper)
  • Sometimes bacteria modify their environment so hard, it kills them (paper)
  • Some ants' bacteria produce the pheromones they use for guidance
  • Modifying plants' microbiota might be difficult due to microbe diversity

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: Apple Podcasts, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Episode outline:

    Monday, April 16, 2018

    BacterioFiles 336 - Phages Fortify Friendly Fighters

    Neutrophil captures Pseudomonas
    aeruginosa
    cells
    By Paulo Henrique Orlandi Mourao,
    CC BY-SA 3.0
    This episode: Phage therapy can work very well when combined with an effective immune response from the host!

    Download Episode (12.9 MB, 14.1 minutes)

    Show notes:
    Microbe of the episode: Gammapapillomavirus 8

    News item about "nightmare bacteria"

    Journal Paper:
    Roach DR, Leung CY, Henry M, Morello E, Singh D, Di Santo JP, Weitz JS, Debarbieux L. 2017. Synergy between the Host Immune System and Bacteriophage Is Essential for Successful Phage Therapy against an Acute Respiratory Pathogen. Cell Host Microbe 22:38-47.e4.

    Other interesting stories:
  • Bacteria make antibacterial silver nanoparticles (paper)
  • Bacteria produce chemical that could enhance effectiveness of penicillin
  • Engineering yeast to produce valuable complex chemicals
  • Specific types of gut microbes affect cancer treatment effectiveness
  • Microbe-produced enzymes could help clean oil spills

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: Apple Podcasts, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Episode outline:

    Monday, April 9, 2018

    BacterioFiles 335 - Purported Paraprobiotic Potential

    Lactobacillus bacteria
    Pelzer et al. 2012
    PLOS One e49965
    This episode: Paraprobiotics, or killed probiotic bacteria, are studied for health effects, but results and study design are questionable!

    Download Episode (11.5 MB, 12.6 minutes)

    Show notes:
    Microbe of the episode: Phlox virus S

    Journal Paper:
    Nishida K, Sawada D, Kawai T, Kuwano Y, Fujiwara S, Rokutan K. 2017. Para-psychobiotic Lactobacillus gasseri CP2305 ameliorates stress-related symptoms and sleep quality. J Appl Microbiol 123:1561–1570.

    Other interesting stories:
  • Parasites infecting ants hide their presence
  • Inoculating soybean crops with extra bacteria can help them fix more nitrogen
  • Microbes help mice recover from bone marrow transplant (paper)
  • Lots of drugs other than antibiotics can harm gut communities (paper)
  • Using biofilm as camera film, for imaging

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

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    Episode outline:

    Monday, April 2, 2018

    BacterioFiles 334 - Measuring Mycelial Moth Muncher Management

    Gypsy moth caterpillar
    By CharlesC, CC BY-SA 4.0
    This episode: Figuring out the best way to study the spread of a fungus that kills an invasive tree-eating caterpillar pest!

    Download Episode (8.2 MB, 8.9 minutes)

    Show notes:
    Microbe of the episode: Pasteurella aerogenes

    News item

    Journal Paper:
    Bittner TD, Hajek AE, Liebhold AM, Thistle H. 2017. Modification of a Pollen Trap Design To Capture Airborne Conidia of Entomophaga maimaiga and Detection of Conidia by Quantitative PCR. Appl Environ Microbiol 83:e00724-17.

    Other interesting stories:

  • Studying the whale microbiome
  • Gut bacteria help herbivorous ants get enough nitrogen
  • Environment factors can affect our microbes apart from genetic factors
  • Fiber could encourage gut microbes to help with type 2 diabetes
  • Gut microbes can affect parasitic worm infections

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: iTunes, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Episode outline:

    Monday, March 26, 2018

    BacterioFiles 333 - Transposons Take Targeting Tool

    Transposon structure
    By Jacek FH, CC BY-SA 3.0
    This episode: Certain transposons, genetic elements that move around the genome on their own, have co-opted the bacterial immune system, CRISPR, to use for jumping to new hosts!

    Thanks to Dr. Joseph Peters for his contribution!
    Download Episode (10.7 MB, 11.75 minutes)

    Show notes:
    Microbe of the episode: Streptomyces yokosukanensis

    Journal Paper:
    Peters JE, Makarova KS, Shmakov S, Koonin EV. 2017. Recruitment of CRISPR-Cas systems by Tn7-like transposons. Proc Natl Acad Sci 114:E7358–E7366.

    Other interesting stories:
  • Microbe found producing antibiotic previously only known to be man-made (paper)
  • Modifying genetics to change bacterial colony colors
  • Making microbe communities that help plants in specific ways
  • Gut microbes can protect mice against death from sepsis
  • Fungus affects cicada behavior to infect more hosts

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: iTunes, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Episode outline: