Monday, July 16, 2018

BacterioFiles 347 - Adenovirus Adapter Allows Assignment

Virus and shielded virus
Schmid et al, 2018, Nat Commun
This episode: Adding adapters to anti-cancer virus helps it avoid destruction by the body so it can target the tumors!

Thanks to Dr. Andreas Plückthun for his contribution!

Download Episode (7.8 MB, 8.5 minutes)

Show notes:
Microbe of the episode: Tomato leaf curl Vietnam virus

News item

Journal Paper:
Schmid M, Ernst P, Honegger A, Suomalainen M, Zimmermann M, Braun L, Stauffer S, Thom C, Dreier B, Eibauer M, Kipar A, Vogel V, Greber UF, Medalia O, Plückthun A. 2018. Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control. Nat Commun 9:450.

Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

Subscribe: Apple Podcasts, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

Episode outline:

Monday, July 9, 2018

BacterioFiles 346 - Prokaryote Prey Plug Picoalgae

Alga (C) with bacterial prey (P)
By: Kamennaya et al,
PLOS Biol 2018
This episode: Very small ocean algae consume bacterial prey of a similar size to themselves by engulfing them only partially!

Download Episode (8.9 MB, 9.7 minutes)

Show notes:
Microbe of the episode: Bradyrhizobium japonicum

Journal Paper:
Kamennaya NA, Kennaway G, Fuchs BM, Zubkov MV. 2018. “Pomacytosis”—Semi-extracellular phagocytosis of cyanobacteria by the smallest marine algae. PLOS Biol 16:e2003502.

Other interesting stories:

  • Using nanomagnets to control quorum sensing by pulling bacteria together (paper)

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: Apple Podcasts, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Episode outline:

    Monday, July 2, 2018

    BacterioFiles 345 - Super Sonic Cell Sacs

    Anabaena flos-aquae,
    a source for gas vesicle genes
    This episode: Protein bags of gas in bacteria could help make ultrasound imaging more versatile!

    Download Episode (7.6 MB, 8.25 minutes)

    Show notes:
    Microbe of the episode: Cronobacter virus Esp2949-1

    News item

    Journal Paper:
    Bourdeau RW, Lee-Gosselin A, Lakshmanan A, Farhadi A, Kumar SR, Nety SP, Shapiro MG. 2018. Acoustic reporter genes for noninvasive imaging of microorganisms in mammalian hosts. Nature 553:86–90.

    Other interesting stories:
  • Laxatives shown very disruptive to gut microbes in mice
  • Evidence not good that probiotics can reduce anxiety in people

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: Apple Podcasts, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Episode outline:

    Monday, June 25, 2018

    BacterioFiles 344 - Bacteriophages Bypass Body Barriers

    Cell culture setup
    Nguyen et al, 2017,
    mBio 8:e01874-17
    This episode: Phages may be passing through the barriers in our body all the time!

    Thanks to Dr. Jeremy Barr for his contribution!
    Download Episode (13.2 MB, 14.5 minutes)

    Show notes:
    Microbe of the episode: Rhodobacter virus RcCronus

    News item

    Journal Paper:
    Nguyen S, Baker K, Padman BS, Patwa R, Dunstan RA, Weston TA, Schlosser K, Bailey B, Lithgow T, Lazarou M, Luque A, Rohwer F, Blumberg RS, Barr JJ. 2017. Bacteriophage Transcytosis Provides a Mechanism To Cross Epithelial Cell Layers. mBio 8:e01874-17.

    Other interesting stories:
  • Yeast species uses same codon for two different amino acids (paper)

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: Apple Podcasts, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Episode outline:

    Sunday, June 17, 2018

    BacterioFiles 343 - Super Cells Save Susceptible Species

    Deinococcus radiodurans
    This episode: Very radiation-resistant bacteria can protect other, less-resistant microbes from some of the effects of chronic radiation!

    Download Episode (9.7 MB, 10.6 minutes)

    Show notes:
    Microbe of the episode: Paramecium bursaria Chlorella virus CA4A

    News item

    Journal Paper:
    Shuryak I, Matrosova VY, Gaidamakova EK, Tkavc R, Grichenko O, Klimenkova P, Volpe RP, Daly MJ. 2017. Microbial cells can cooperate to resist high-level chronic ionizing radiation. PLOS ONE 12:e0189261.

    Other interesting stories:
  • Panda gut microbes help them detoxify cyanide in their diet (paper)
  • Modified probiotics can detect and inhibit cholera in baby mice

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: Apple Podcasts, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Episode outline:

    Monday, June 11, 2018

    BacterioFiles 342 - Cyanide Stops Cell Suckers

    Chromobacterium growing on agar
    This episode: Some bacteria can defend themselves from bacterial predators by producing cyanide!

    Thanks to Dr. Robert Mitchell for his contribution!

    Download Episode (7.7 MB, 8.4 minutes)

    Show notes:
    Microbe of the episode: Dyoepsilonpapillomavirus 1

    News item

    Journal Paper:
    Mun W, Kwon H, Im H, Choi SY, Monnappa AK, Mitchell RJ. 2017. Cyanide Production by Chromobacterium piscinae Shields It from Bdellovibrio bacteriovorus HD100 Predation. mBio 8:e01370-17.

    Other interesting stories:
  • Using bacterial DNA to estimate movement of river water
  • Making bacteria produce biologic drugs that last longer in the body
  • Fungal pigment could be a useful semiconductor
  • Parasitic microbe uses chemical defense against defenses of fungus-growing ants

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: Apple Podcasts, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Episode outline:

    Monday, June 4, 2018

    BacterioFiles 341 - Cancer Killer Could Cure Cryptic Contagion

    HIV particles on infected cell
    By Liza Gross,
    PLOS Biology 2006, e445
    CC BY 2.5
    This episode: A virus designed to target cancer could also help eliminate hidden HIV infections!

    Thanks to Nischal Ranganath for his contribution!

    Download Episode (8.7 MB, 9.5 minutes)

    Show notes:
    Microbe of the episode: Streptomyces pluricolorescens

    News item

    Journal Paper:
    Ranganath N, Sandstrom TS, Schinkel B, C S, Côté SC, Angel JB. 2018. The Oncolytic Virus MG1 Targets and Eliminates Cells Latently Infected With HIV-1: Implications for an HIV Cure. J Infect Dis 217:721–730.

    Other interesting stories:
  • Gut microbes could affect immune defense against liver cancer

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: Apple Podcasts, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Episode outline:

    Sunday, May 27, 2018

    BacterioFiles 340 - Plasmid Promotes Plant Pathogenesis

    Pathogenic Rhodococcus causing
    disfigurement
    From: Savory et al, eLife 6:e30925
    This episode: Some bacteria living around plants can become pathogenic just by gaining a few genes!

    Thanks to Skylar Fuller for her contribution!

    Download Episode (9.4 MB, 10.3 minutes)

    Show notes:
    Microbe of the episode: Alternanthera yellow vein betasatellite

    News item

    Journal Paper:
    Savory EA, Fuller SL, Weisberg AJ, Thomas WJ, Gordon MI, Stevens DM, Creason AL, Belcher MS, Serdani M, Wiseman MS, Grünwald NJ, Putnam ML, Chang JH. 2017. Evolutionary transitions between beneficial and phytopathogenic Rhodococcus challenge disease management. eLife 6:e30925.

    Other interesting stories:
  • More gut microbe diversity could be good for arteries
  • Human gut microbes have enzymes that break down specific plant toxins (paper)
  • Gut microbes ferment fiber and modify immune response to protect mice from flu
  • Cooperation of plants and fungi breaks down if one finds alternative lifestyle (paper)
  • Disproven "arsenic in the DNA" bacterium actually has interesting arsenic detox strategies (paper)

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: Apple Podcasts, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Episode outline:

    Monday, May 21, 2018

    BacterioFiles 339 - Medical Microbiota Measurement

    Clostridium difficile bacteria
    This episode: Fecal microbiota transplants work just as well when taken in pill form as when delivered through a tube!

    Download Episode (10.5 MB, 11.5 minutes)

    Show notes:
    Microbe of the episode: Halobacterium halobium

    News item

    Journal Paper:
    Kao D, Roach B, Silva M, Beck P, Rioux K, Kaplan GG, Chang H-J, Coward S, Goodman KJ, Xu H, Madsen K, Mason A, Wong GK-S, Jovel J, Patterson J, Louie T. 2017. Effect of Oral Capsule- vs Colonoscopy-Delivered Fecal Microbiota Transplantation on Recurrent Clostridium difficile Infection: A Randomized Clinical Trial. J Am Med Assoc 318:1985–1993.

    Other interesting stories:
  • Protein that can form prions important for protecting mice from influenza (paper)
  • Figuring out how bacteria in fruit flies kill only males
  • Healthy skin microbes could help treat eczema
  • Good gut microbe is very comfortable with immune system
  • Archaea in bogs could be good microbes for plants too (paper)

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: Apple Podcasts, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Episode outline:

    Monday, May 14, 2018

    BacterioFiles 338 - Maverick Mouse Microbes Mitigate Maladies

    House mouse,
    Mus musculus domesticus
    This episode: Gut microbe transplants from wild mice protect lab mice from disease!

    Download Episode (9.8 MB, 10.7 minutes)

    Show notes:
    Microbe of the episode: Cabassou virus

    News item

    Journal Paper:
    Rosshart SP, Vassallo BG, Angeletti D, Hutchinson DS, Morgan AP, Takeda K, Hickman HD, McCulloch JA, Badger JH, Ajami NJ, Trinchieri G, Pardo-Manuel de Villena F, Yewdell JW, Rehermann B. 2017. Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance. Cell 171:1015-1028.e13.

    Other interesting stories:
  • Phage cocktail can eliminate pathogen with minimal collateral damage
  • Preventive probiotics given with antibiotics can help keep C. diff away
  • Early exposure to dust and bacteria linked with less immune response to stress
  • Viruses that help wasps parasitize caterpillars also inhibit plant defenses
  • Only one microbe species can live in extremely acidic, almost boiling lake

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: Apple Podcasts, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Episode outline:

    Monday, April 30, 2018

    BacterioFiles 337 - Gathering Gut Groupings Graphics

    Bacteria labeled using FISH
    By Velocity2222X
    CC BY-SA 3.0
    This episode: A simplified bacterial community in mouse guts doesn't have much community structure, relative to other body areas!

    Download Episode (8.8 MB, 9.6 minutes)

    Show notes:
    Microbe of the episode: Rhodomicrobium vannielii

    News item

    Journal Paper:
    Welch JLM, Hasegawa Y, McNulty NP, Gordon JI, Borisy GG. 2017. Spatial organization of a model 15-member human gut microbiota established in gnotobiotic mice. Proc Natl Acad Sci 114:E9105–E9114.

    Other interesting stories:
  • Studying the microbes found in Chinese hazy air (paper)
  • Sometimes bacteria modify their environment so hard, it kills them (paper)
  • Some ants' bacteria produce the pheromones they use for guidance
  • Modifying plants' microbiota might be difficult due to microbe diversity

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: Apple Podcasts, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Episode outline:

    Monday, April 16, 2018

    BacterioFiles 336 - Phages Fortify Friendly Fighters

    Neutrophil captures Pseudomonas
    aeruginosa
    cells
    By Paulo Henrique Orlandi Mourao,
    CC BY-SA 3.0
    This episode: Phage therapy can work very well when combined with an effective immune response from the host!

    Download Episode (12.9 MB, 14.1 minutes)

    Show notes:
    Microbe of the episode: Gammapapillomavirus 8

    News item about "nightmare bacteria"

    Journal Paper:
    Roach DR, Leung CY, Henry M, Morello E, Singh D, Di Santo JP, Weitz JS, Debarbieux L. 2017. Synergy between the Host Immune System and Bacteriophage Is Essential for Successful Phage Therapy against an Acute Respiratory Pathogen. Cell Host Microbe 22:38-47.e4.

    Other interesting stories:
  • Bacteria make antibacterial silver nanoparticles (paper)
  • Bacteria produce chemical that could enhance effectiveness of penicillin
  • Engineering yeast to produce valuable complex chemicals
  • Specific types of gut microbes affect cancer treatment effectiveness
  • Microbe-produced enzymes could help clean oil spills

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: Apple Podcasts, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Episode outline:

    Monday, April 9, 2018

    BacterioFiles 335 - Purported Paraprobiotic Potential

    Lactobacillus bacteria
    Pelzer et al. 2012
    PLOS One e49965
    This episode: Paraprobiotics, or killed probiotic bacteria, are studied for health effects, but results and study design are questionable!

    Download Episode (11.5 MB, 12.6 minutes)

    Show notes:
    Microbe of the episode: Phlox virus S

    Journal Paper:
    Nishida K, Sawada D, Kawai T, Kuwano Y, Fujiwara S, Rokutan K. 2017. Para-psychobiotic Lactobacillus gasseri CP2305 ameliorates stress-related symptoms and sleep quality. J Appl Microbiol 123:1561–1570.

    Other interesting stories:
  • Parasites infecting ants hide their presence
  • Inoculating soybean crops with extra bacteria can help them fix more nitrogen
  • Microbes help mice recover from bone marrow transplant (paper)
  • Lots of drugs other than antibiotics can harm gut communities (paper)
  • Using biofilm as camera film, for imaging

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: iTunes, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Episode outline:

    Monday, April 2, 2018

    BacterioFiles 334 - Measuring Mycelial Moth Muncher Management

    Gypsy moth caterpillar
    By CharlesC, CC BY-SA 4.0
    This episode: Figuring out the best way to study the spread of a fungus that kills an invasive tree-eating caterpillar pest!

    Download Episode (8.2 MB, 8.9 minutes)

    Show notes:
    Microbe of the episode: Pasteurella aerogenes

    News item

    Journal Paper:
    Bittner TD, Hajek AE, Liebhold AM, Thistle H. 2017. Modification of a Pollen Trap Design To Capture Airborne Conidia of Entomophaga maimaiga and Detection of Conidia by Quantitative PCR. Appl Environ Microbiol 83:e00724-17.

    Other interesting stories:

  • Studying the whale microbiome
  • Gut bacteria help herbivorous ants get enough nitrogen
  • Environment factors can affect our microbes apart from genetic factors
  • Fiber could encourage gut microbes to help with type 2 diabetes
  • Gut microbes can affect parasitic worm infections

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: iTunes, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Episode outline:

    Monday, March 26, 2018

    BacterioFiles 333 - Transposons Take Targeting Tool

    Transposon structure
    By Jacek FH, CC BY-SA 3.0
    This episode: Certain transposons, genetic elements that move around the genome on their own, have co-opted the bacterial immune system, CRISPR, to use for jumping to new hosts!

    Thanks to Dr. Joseph Peters for his contribution!
    Download Episode (10.7 MB, 11.75 minutes)

    Show notes:
    Microbe of the episode: Streptomyces yokosukanensis

    Journal Paper:
    Peters JE, Makarova KS, Shmakov S, Koonin EV. 2017. Recruitment of CRISPR-Cas systems by Tn7-like transposons. Proc Natl Acad Sci 114:E7358–E7366.

    Other interesting stories:
  • Microbe found producing antibiotic previously only known to be man-made (paper)
  • Modifying genetics to change bacterial colony colors
  • Making microbe communities that help plants in specific ways
  • Gut microbes can protect mice against death from sepsis
  • Fungus affects cicada behavior to infect more hosts

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: iTunes, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Episode outline:

    Monday, March 19, 2018

    BacterioFiles 332 - Moth Minors Missing Microbes

    Manduca sexta caterpillar,
    tobacco hornworm
    This episode: Unlike most animals, caterpillars don't seem to have a resident gut microbe to help them in various ways!

    Thanks to Tobin Hammer for his contribution!
    Download Episode (14 MB, 15.3 minutes)

    Show notes:
    Microbe of the episode: Borrelia graingeri

    News item

    Journal Paper:
    Hammer TJ, Janzen DH, Hallwachs W, Jaffe SP, Fierer N. 2017. Caterpillars lack a resident gut microbiome. Proc Natl Acad Sci 114:9641–9646.

    Other interesting stories:
  • Improving viral delivery of gene therapy across blood-brain barrier
  • Engineered gut bacteria bind bowel cancer and kill it with vegetables
  • Making bacteria into synthetic phage factories (paper)
  • Preventing contamination of industrial algae cultures using predatory bacteria (paper)
  • Finding potential new antibiotics in cockroach microbes (paper)

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: iTunes, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Episode outline:

    Monday, March 12, 2018

    BacterioFiles 331 - Password Protein Poisons Pairings

    Myxobacteria fruiting bodies
    By Trance Gemini, CC-BY 3.0
    This episode: How social bacteria societies function: by sharing enzyme packages with each other that can contain toxins that are deadly for rivals but not for friends!

    Thanks to Chris Vasallo for his contribution!
    Download Episode (12.4 MB, 13.6 minutes)

    Show notes:
    Microbe of the episode: Propionibacterium virus PAD20

    News item

    Journal Paper:
    Vassallo CN, Cao P, Conklin A, Finkelstein H, Hayes CS, Wall D. 2017. Infectious polymorphic toxins delivered by outer membrane exchange discriminate kin in myxobacteria. eLife 6:e29397.

    Other interesting stories:
  • Attaching proteins to little bioplastic beads to make useful nanoparticles (paper)
  • Fungi are very important for nutrient cycling in the world
  • Friendly soil microbes inject plant pathogens with toxin
  • Microbes are carried around the world through the atmosphere
  • Arctic algae can grow even in super cold and dark conditions

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: iTunes, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Episode outline:

    Monday, March 5, 2018

    BacterioFiles 330 - Polar Plasmid Produces Particles

    Plasmid DNA
    By de:Benutzer:Sec11, CC BY-SA 3.0
    This episode: A plasmid discovered in Antarctic archaea can create virus-like particles, membrane vesicles, and transfer itself to new hosts!

    Thanks to Rick Cavicchioli for his contribution.
    Download Episode (17.7 MB, 19.4 minutes)

    Show notes:
    Microbe of the episode: Hypomicrogaster canadensis bracovirus

    News item

    Journal Paper:
    Erdmann S, Tschitschko B, Zhong L, Raftery MJ, Cavicchioli R. 2017. A plasmid from an Antarctic haloarchaeon uses specialized membrane vesicles to disseminate and infect plasmid-free cells. Nat Microbiol 2:1446.

    Other interesting stories:
  • Probiotic bacteria good at metabolizing potentially helpful plant compounds (paper)
  • Bacteria can harvest precious metals from waste to make catalytic particles (paper)
  • Bacteria help mice avoid chemotherapy-induced autoimmunity (paper)
  • Exercise could be healthy partly because it modifies gut microbe community
  • Gut microbe community may help some bats live long (paper)

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: iTunes, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Episode outline:

    Monday, February 26, 2018

    BacterioFiles 329 - Special Secreting Structure Studied

    Type 6 Secretion System protein
    By User:Astrojan, CC-BY 4.0
    This episode: New type of secretion system discovered that bacteria use to stab amoeba predators to escape their digestion!

    Download Episode (7.8 MB, 8.5 minutes)

    Show notes:
    Microbe of the episode: Avastrovirus 1

    News item

    Journal Paper:
    Böck D, Medeiros JM, Tsao H-F, Penz T, Weiss GL, Aistleitner K, Horn M, Pilhofer M. 2017. In situ architecture, function, and evolution of a contractile injection system. Science 357:713–717.

    Other interesting stories:
  • Gut microbe metabolites keep yeasts from taking over (paper)
  • Ancient fungi extracted minerals that helped ancient plants create oxygen
  • How microbes survive on and affect tombstones (paper)
  • Stomach bacterium produces interesting anti-inflammatory compound (paper)
  • Finding archaea in the human lung, gut, skin, and nose (paper)

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: iTunes, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Episode outline:

    Monday, February 19, 2018

    No episode this week

    No episode this week. I am working on getting some papers published! Stay tuned.

    Monday, February 12, 2018

    BacterioFiles 328 - Focused Phages Fight Films

    Bacteriophages
    By Sherwood Casjens,Elaine Lenk
    CC BY-SA 3.0
    This episode: Phages bound to magnetic nanoparticles can be guided and pulled toward their target, penetrating biofilms to kill harmful microbes!

    Download Episode (9.6 MB, 10.4 minutes)

    Show notes:
    Microbe of the episode: Veillonella alcalescens

    News item

    Journal Paper:
    Li L-L, Yu P, Wang X, Yu S-S, Mathieu J, Yu H-Q, Alvarez PJJ. 2017. Enhanced biofilm penetration for microbial control by polyvalent phages conjugated with magnetic colloidal nanoparticle clusters (CNCs). Environ Sci Nano 4:1817–1826.

    Other interesting stories:
  • Social group membership affects lemur gut microbes
  • Viruses can transfer genes between kingdoms
  • Trace gases in atmosphere enough to support microbes in Antarctica
  • Magnetic bacteria can swim even against the current
  • Engineered bacteria produce internal scaffolds for better biotech productions

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: iTunes, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Episode outline:

    Monday, February 5, 2018

    BacterioFiles 327 - Microbe Metabolite Meliorates Malaise

    Influenza virus particles
    This episode: Gut microbes in mice break down plant foods and produce molecules that stimulate the immune system to resist influenza!

    Thanks to Drs. Ashley Steed and Thaddeus Stappenbeck for their contributions!
    Download Episode (9 MB, 9.8 minutes)

    Show notes:
    Microbe of the episode: Bougainvillea chlorotic vein banding virus

    News item

    Journal Paper:
    Steed AL, Christophi GP, Kaiko GE, Sun L, Goodwin VM, Jain U, Esaulova E, Artyomov MN, Morales DJ, Holtzman MJ, Boon ACM, Lenschow DJ, Stappenbeck TS. 2017. The microbial metabolite desaminotyrosine protects from influenza through type I interferon. Science 357:498–502.

    Other interesting stories:
  • Nanobots with propellers modeled after bacterial flagella
  • Embedding useful bacteria into "ink" used to print 3D structures
  • Controlling behavior of individual bacteria using a computer
  • Exercise alone can affect microbiota
  • Microbes in ISS are similar to microbes in Earth homes

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: iTunes, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Episode outline:

    Monday, January 29, 2018

    BacterioFiles 326 - Ciliate Symbionts Selected Separately

    Euplotes ciliates
    This episode: Learning about endosymbionts by comparing bacteria living inside eukaryotes to their free-living cousins!

    Thanks to Dr. Vittorio Boscaro for his contribution!
    Download Episode (9.7 MB, 10.6 minutes)

    Show notes:
    Microbe of the episode: Ancalochloris perfilievii

    Journal Paper:
    Boscaro V, Kolisko M, Felletti M, Vannini C, Lynn DH, Keeling PJ. 2017. Parallel genome reduction in symbionts descended from closely related free-living bacteria. Nat Ecol Evol 1:1160.

    Other interesting stories:
  • Wolbachia naturally found in mosquitoes inhibits malaria transmission (paper)
  • Group of 5 microbes help regulate Hydra's body contractions
  • In mice, fungi can function somewhat in place of gut bacteria (paper)
  • Bacteriophages get carried all over the body
  • Bacteria engineered to make boron-carbon bonds

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: iTunes, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Episode outline:

    Monday, January 22, 2018

    BacterioFiles 325 - Moisture Mobilizes Mycelium Multiples

    Mushroom spore print
    This episode: Figuring out how mushrooms launch their spores out using a trick of water surface tension!

    Download Episode (6.7 MB, 7.3 minutes)

    Show notes:
    Microbe of the episode: Carrot torradovirus 1

    News item

    Video of artificial "spore" launching

    Journal Paper:
    Liu F, Chavez RL, Patek SN, Pringle A, Feng JJ, Chen C-H. 2017. Asymmetric drop coalescence launches fungal ballistospores with directionality. J R Soc Interface 14:20170083.

    Other interesting stories:
  • Bacteriophage also inhibits fungal pathogen (paper)
  • Virus infects both plant and fungus (paper)
  • Gut interactions between bacteria and salt - also this
  • Bacteria can transform toxic metals into less harmful forms (paper)
  • Microbes generating electricity from swine wastewater

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: iTunes, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Episode outline:

    Monday, January 15, 2018

    BacterioFiles 324 - Prokaryote Prefers Poorer Power

    Green Dragon Spring, Yellowstone
    Credit: National Park Service
    This episode: Hot spring archaea prefer to use elements that give them less energy even when more energetic options are available!

    Download Episode (8.1 MB, 8.8 minutes)

    Show notes:
    Microbe of the episode: Vitreoscilla beggiatoides

    News item

    Journal Paper:
    Amenabar MJ, Shock EL, Roden EE, Peters JW, Boyd ES. 2017. Microbial substrate preference dictated by energy demand rather than supply. Nat Geosci 10:577–581.

    Other interesting stories:
  • Developing good methods for using skin microbiome for forensics (paper)
  • Microbe discovered that consumes groundwater contaminant dioxane
  • Mucus-eating gut microbes can produce beneficial nutrients and vitamins (paper)
  • Making new beer and wine flavors with different yeast
  • Providing leaf microbiota to help endangered plants survive in wild

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: iTunes, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Episode outline:

    Monday, January 8, 2018

    BacterioFiles 323 - Clostridium Capturing Carbon with Walter Sandoval

    Walter Sandoval in lab
    This episode: I talk with Dr. Walter Sandoval-Espinola, a researcher from Paraguay, now a postdoc at Harvard, about his discovery that biofuel-producing bacteria Clostridium beijerinckii can also transform CO2 and carbon monoxide into biofuels!

    Download Episode (37 MB, 40.4 minutes)

    Show notes:
    News item en español

    Find Walter on Twitter or LinkedIn

    Journal Paper:
    Sandoval-Espinola WJ, Chinn MS, Thon MR, Bruno-Bárcena JM. 2017. Evidence of mixotrophic carbon-capture by n-butanol-producer Clostridium beijerinckii. Sci Rep 7:12759.

    Other interesting stories:
  • Even microbes can help mix up lake water
  • Using drones to sample whale microbiome
  • Prebiotics could affect gut even without microbe involvement (paper)
  • Bacteria do better in changing environments when they cooperate
  • Newly discovered bacterial defense against phages (paper)

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: iTunes, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Monday, January 1, 2018

    BacterioFiles 322 - Parents' Partners Protect Plants

    Cacao tree with fruit pods
    By Luisovalles
    Own work, CC BY 3.0
    Happy New Year! This episode: Fungal endophytes transferred from healthy adult plant leaf litter help baby cacao plants resist disease!

    Thanks to Dr. Natalie Christian for her contribution!

    Download Episode (10.3 MB, 11.25 minutes)

    Show notes:
    Microbe of the episode: Lactobacillus virus Lb338-1

    News item
    Hear a CBC interview with Dr. Christian about this research

    Journal Paper:
    Christian N, Herre EA, Mejia LC, Clay K. 2017. Exposure to the leaf litter microbiome of healthy adults protects seedlings from pathogen damage. Proc R Soc B 284:20170641.

    Other interesting stories:
  • Using bacteria to clean up radioactive strontium from water (paper)
  • Ocean bacteria make themselves slippery instead of sticky to avoid predators (paper)
  • Which plants grow in tropics depends on how fungi interact with their seeds
  • Using an antibiotic-sensing protein to control antibiotic production in bacteria
  • Symbiotic fungi can help plants tolerate stresses better

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: iTunes, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Episode outline: