Sunday, April 22, 2018

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Monday, April 16, 2018

BacterioFiles 336 - Phages Fortify Friendly Fighters

Neutrophil captures Pseudomonas
aeruginosa
cells
By Paulo Henrique Orlandi Mourao,
CC BY-SA 3.0
This episode: Phage therapy can work very well when combined with an effective immune response from the host!

Download Episode (12.9 MB, 14.1 minutes)

Show notes:
Microbe of the episode: Gammapapillomavirus 8

News item about "nightmare bacteria"

Journal Paper:
Roach DR, Leung CY, Henry M, Morello E, Singh D, Di Santo JP, Weitz JS, Debarbieux L. 2017. Synergy between the Host Immune System and Bacteriophage Is Essential for Successful Phage Therapy against an Acute Respiratory Pathogen. Cell Host Microbe 22:38-47.e4.

Other interesting stories:
  • Bacteria make antibacterial silver nanoparticles (paper)
  • Bacteria produce chemical that could enhance effectiveness of penicillin
  • Engineering yeast to produce valuable complex chemicals
  • Specific types of gut microbes affect cancer treatment effectiveness
  • Microbe-produced enzymes could help clean oil spills

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: Apple Podcasts, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Episode outline:

    Monday, April 9, 2018

    BacterioFiles 335 - Purported Paraprobiotic Potential

    Lactobacillus bacteria
    Pelzer et al. 2012
    PLOS One e49965
    This episode: Paraprobiotics, or killed probiotic bacteria, are studied for health effects, but results and study design are questionable!

    Download Episode (11.5 MB, 12.6 minutes)

    Show notes:
    Microbe of the episode: Phlox virus S

    Journal Paper:
    Nishida K, Sawada D, Kawai T, Kuwano Y, Fujiwara S, Rokutan K. 2017. Para-psychobiotic Lactobacillus gasseri CP2305 ameliorates stress-related symptoms and sleep quality. J Appl Microbiol 123:1561–1570.

    Other interesting stories:
  • Parasites infecting ants hide their presence
  • Inoculating soybean crops with extra bacteria can help them fix more nitrogen
  • Microbes help mice recover from bone marrow transplant (paper)
  • Lots of drugs other than antibiotics can harm gut communities (paper)
  • Using biofilm as camera film, for imaging

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: iTunes, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Episode outline:

    Monday, April 2, 2018

    BacterioFiles 334 - Measuring Mycelial Moth Muncher Management

    Gypsy moth caterpillar
    By CharlesC, CC BY-SA 4.0
    This episode: Figuring out the best way to study the spread of a fungus that kills an invasive tree-eating caterpillar pest!

    Download Episode (8.2 MB, 8.9 minutes)

    Show notes:
    Microbe of the episode: Pasteurella aerogenes

    News item

    Journal Paper:
    Bittner TD, Hajek AE, Liebhold AM, Thistle H. 2017. Modification of a Pollen Trap Design To Capture Airborne Conidia of Entomophaga maimaiga and Detection of Conidia by Quantitative PCR. Appl Environ Microbiol 83:e00724-17.

    Other interesting stories:

  • Studying the whale microbiome
  • Gut bacteria help herbivorous ants get enough nitrogen
  • Environment factors can affect our microbes apart from genetic factors
  • Fiber could encourage gut microbes to help with type 2 diabetes
  • Gut microbes can affect parasitic worm infections

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: iTunes, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Episode outline:

    Monday, March 26, 2018

    BacterioFiles 333 - Transposons Take Targeting Tool

    Transposon structure
    By Jacek FH, CC BY-SA 3.0
    This episode: Certain transposons, genetic elements that move around the genome on their own, have co-opted the bacterial immune system, CRISPR, to use for jumping to new hosts!

    Thanks to Dr. Joseph Peters for his contribution!
    Download Episode (10.7 MB, 11.75 minutes)

    Show notes:
    Microbe of the episode: Streptomyces yokosukanensis

    Journal Paper:
    Peters JE, Makarova KS, Shmakov S, Koonin EV. 2017. Recruitment of CRISPR-Cas systems by Tn7-like transposons. Proc Natl Acad Sci 114:E7358–E7366.

    Other interesting stories:
  • Microbe found producing antibiotic previously only known to be man-made (paper)
  • Modifying genetics to change bacterial colony colors
  • Making microbe communities that help plants in specific ways
  • Gut microbes can protect mice against death from sepsis
  • Fungus affects cicada behavior to infect more hosts

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: iTunes, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Episode outline:

    Monday, March 19, 2018

    BacterioFiles 332 - Moth Minors Missing Microbes

    Manduca sexta caterpillar,
    tobacco hornworm
    This episode: Unlike most animals, caterpillars don't seem to have a resident gut microbe to help them in various ways!

    Thanks to Tobin Hammer for his contribution!
    Download Episode (14 MB, 15.3 minutes)

    Show notes:
    Microbe of the episode: Borrelia graingeri

    News item

    Journal Paper:
    Hammer TJ, Janzen DH, Hallwachs W, Jaffe SP, Fierer N. 2017. Caterpillars lack a resident gut microbiome. Proc Natl Acad Sci 114:9641–9646.

    Other interesting stories:
  • Improving viral delivery of gene therapy across blood-brain barrier
  • Engineered gut bacteria bind bowel cancer and kill it with vegetables
  • Making bacteria into synthetic phage factories (paper)
  • Preventing contamination of industrial algae cultures using predatory bacteria (paper)
  • Finding potential new antibiotics in cockroach microbes (paper)

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: iTunes, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Episode outline:

    Monday, March 12, 2018

    BacterioFiles 331 - Password Protein Poisons Pairings

    Myxobacteria fruiting bodies
    By Trance Gemini, CC-BY 3.0
    This episode: How social bacteria societies function: by sharing enzyme packages with each other that can contain toxins that are deadly for rivals but not for friends!

    Thanks to Chris Vasallo for his contribution!
    Download Episode (12.4 MB, 13.6 minutes)

    Show notes:
    Microbe of the episode: Propionibacterium virus PAD20

    News item

    Journal Paper:
    Vassallo CN, Cao P, Conklin A, Finkelstein H, Hayes CS, Wall D. 2017. Infectious polymorphic toxins delivered by outer membrane exchange discriminate kin in myxobacteria. eLife 6:e29397.

    Other interesting stories:
  • Attaching proteins to little bioplastic beads to make useful nanoparticles (paper)
  • Fungi are very important for nutrient cycling in the world
  • Friendly soil microbes inject plant pathogens with toxin
  • Microbes are carried around the world through the atmosphere
  • Arctic algae can grow even in super cold and dark conditions

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: iTunes, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Episode outline: