Sunday, June 17, 2018

BacterioFiles 343 - Super Cells Save Susceptible Species

Deinococcus radiodurans
This episode: Very radiation-resistant bacteria can protect other, less-resistant microbes from some of the effects of chronic radiation!

Download Episode (9.7 MB, 10.6 minutes)

Show notes:
Microbe of the episode: Paramecium bursaria Chlorella virus CA4A

News item

Journal Paper:
Shuryak I, Matrosova VY, Gaidamakova EK, Tkavc R, Grichenko O, Klimenkova P, Volpe RP, Daly MJ. 2017. Microbial cells can cooperate to resist high-level chronic ionizing radiation. PLOS ONE 12:e0189261.

Other interesting stories:
  • Panda gut microbes help them detoxify cyanide in their diet (paper)
  • Modified probiotics can detect and inhibit cholera in baby mice

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

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    Episode outline:

    Monday, June 11, 2018

    BacterioFiles 342 - Cyanide Stops Cell Suckers

    Chromobacterium growing on agar
    This episode: Some bacteria can defend themselves from bacterial predators by producing cyanide!

    Thanks to Dr. Robert Mitchell for his contribution!

    Download Episode (7.7 MB, 8.4 minutes)

    Show notes:
    Microbe of the episode: Dyoepsilonpapillomavirus 1

    News item

    Journal Paper:
    Mun W, Kwon H, Im H, Choi SY, Monnappa AK, Mitchell RJ. 2017. Cyanide Production by Chromobacterium piscinae Shields It from Bdellovibrio bacteriovorus HD100 Predation. mBio 8:e01370-17.

    Other interesting stories:
  • Using bacterial DNA to estimate movement of river water
  • Making bacteria produce biologic drugs that last longer in the body
  • Fungal pigment could be a useful semiconductor
  • Parasitic microbe uses chemical defense against defenses of fungus-growing ants

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

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    Episode outline:

    Monday, June 4, 2018

    BacterioFiles 341 - Cancer Killer Could Cure Cryptic Contagion

    HIV particles on infected cell
    By Liza Gross,
    PLOS Biology 2006, e445
    CC BY 2.5
    This episode: A virus designed to target cancer could also help eliminate hidden HIV infections!

    Thanks to Nischal Ranganath for his contribution!

    Download Episode (8.7 MB, 9.5 minutes)

    Show notes:
    Microbe of the episode: Streptomyces pluricolorescens

    News item

    Journal Paper:
    Ranganath N, Sandstrom TS, Schinkel B, C S, Côté SC, Angel JB. 2018. The Oncolytic Virus MG1 Targets and Eliminates Cells Latently Infected With HIV-1: Implications for an HIV Cure. J Infect Dis 217:721–730.

    Other interesting stories:
  • Gut microbes could affect immune defense against liver cancer

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

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    Episode outline:

    Sunday, May 27, 2018

    BacterioFiles 340 - Plasmid Promotes Plant Pathogenesis

    Pathogenic Rhodococcus causing
    disfigurement
    From: Savory et al, eLife 6:e30925
    This episode: Some bacteria living around plants can become pathogenic just by gaining a few genes!

    Thanks to Skylar Fuller for her contribution!

    Download Episode (9.4 MB, 10.3 minutes)

    Show notes:
    Microbe of the episode: Alternanthera yellow vein betasatellite

    News item

    Journal Paper:
    Savory EA, Fuller SL, Weisberg AJ, Thomas WJ, Gordon MI, Stevens DM, Creason AL, Belcher MS, Serdani M, Wiseman MS, Grünwald NJ, Putnam ML, Chang JH. 2017. Evolutionary transitions between beneficial and phytopathogenic Rhodococcus challenge disease management. eLife 6:e30925.

    Other interesting stories:
  • More gut microbe diversity could be good for arteries
  • Human gut microbes have enzymes that break down specific plant toxins (paper)
  • Gut microbes ferment fiber and modify immune response to protect mice from flu
  • Cooperation of plants and fungi breaks down if one finds alternative lifestyle (paper)
  • Disproven "arsenic in the DNA" bacterium actually has interesting arsenic detox strategies (paper)

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

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    Episode outline:

    Monday, May 21, 2018

    BacterioFiles 339 - Medical Microbiota Measurement

    Clostridium difficile bacteria
    This episode: Fecal microbiota transplants work just as well when taken in pill form as when delivered through a tube!

    Download Episode (10.5 MB, 11.5 minutes)

    Show notes:
    Microbe of the episode: Halobacterium halobium

    News item

    Journal Paper:
    Kao D, Roach B, Silva M, Beck P, Rioux K, Kaplan GG, Chang H-J, Coward S, Goodman KJ, Xu H, Madsen K, Mason A, Wong GK-S, Jovel J, Patterson J, Louie T. 2017. Effect of Oral Capsule- vs Colonoscopy-Delivered Fecal Microbiota Transplantation on Recurrent Clostridium difficile Infection: A Randomized Clinical Trial. J Am Med Assoc 318:1985–1993.

    Other interesting stories:
  • Protein that can form prions important for protecting mice from influenza (paper)
  • Figuring out how bacteria in fruit flies kill only males
  • Healthy skin microbes could help treat eczema
  • Good gut microbe is very comfortable with immune system
  • Archaea in bogs could be good microbes for plants too (paper)

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

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    Episode outline:

    Monday, May 14, 2018

    BacterioFiles 338 - Maverick Mouse Microbes Mitigate Maladies

    House mouse,
    Mus musculus domesticus
    This episode: Gut microbe transplants from wild mice protect lab mice from disease!

    Download Episode (9.8 MB, 10.7 minutes)

    Show notes:
    Microbe of the episode: Cabassou virus

    News item

    Journal Paper:
    Rosshart SP, Vassallo BG, Angeletti D, Hutchinson DS, Morgan AP, Takeda K, Hickman HD, McCulloch JA, Badger JH, Ajami NJ, Trinchieri G, Pardo-Manuel de Villena F, Yewdell JW, Rehermann B. 2017. Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance. Cell 171:1015-1028.e13.

    Other interesting stories:
  • Phage cocktail can eliminate pathogen with minimal collateral damage
  • Preventive probiotics given with antibiotics can help keep C. diff away
  • Early exposure to dust and bacteria linked with less immune response to stress
  • Viruses that help wasps parasitize caterpillars also inhibit plant defenses
  • Only one microbe species can live in extremely acidic, almost boiling lake

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

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    Episode outline:

    Monday, April 30, 2018

    BacterioFiles 337 - Gathering Gut Groupings Graphics

    Bacteria labeled using FISH
    By Velocity2222X
    CC BY-SA 3.0
    This episode: A simplified bacterial community in mouse guts doesn't have much community structure, relative to other body areas!

    Download Episode (8.8 MB, 9.6 minutes)

    Show notes:
    Microbe of the episode: Rhodomicrobium vannielii

    News item

    Journal Paper:
    Welch JLM, Hasegawa Y, McNulty NP, Gordon JI, Borisy GG. 2017. Spatial organization of a model 15-member human gut microbiota established in gnotobiotic mice. Proc Natl Acad Sci 114:E9105–E9114.

    Other interesting stories:
  • Studying the microbes found in Chinese hazy air (paper)
  • Sometimes bacteria modify their environment so hard, it kills them (paper)
  • Some ants' bacteria produce the pheromones they use for guidance
  • Modifying plants' microbiota might be difficult due to microbe diversity

  • Post questions or comments here or email to bacteriofiles@gmail.com. Thanks for listening!

    Subscribe: Apple Podcasts, RSS, Google Play. Support the show at Patreon, or check out the show at Twitter or Facebook.

    Episode outline: